Mothibistad is a town situated alongside the N14 National Route and R31 Provincial Route in the Northern Cape Province of South Africa, approximately 9 km north-east of Kuruman.
Before 1994, the town it was part of the Bophuthatswana bantustan. From 1994, until a border change in 2006 it was in North West Province.
Mothibistad falls within the Ga-Segonyana Local Municipality and the John Taolo Gaetsewe District Municipality.
The town is the administrative centre/seat of the neighbouring Joe Morolong Local Municipality.