Blythswood is a former Presbyterian mission station near Gcuwa (formerly Butterworth) in the Eastern Cape Province of South Africa.
Blythswood was named after Captain Matthew T Blyth, the first Chief Magistrate of the Transkei.
Blythswood is an important educational centre and falls within the Mnquma Local Municipality and the Amathole District Municipality.
The Nqamakwe rock art site, showcasing some examples of Khoisan rock art, is relatively close to the settlement.